This document describes a comprehensive alert and response framework designed to ensure early detection, timely notification, and rapid response to public health events. It defines surveillance structures, reporting pathways, verification procedures, and escalation thresholds across different administrative levels. The framework details roles and responsibilities of health authorities, rapid response teams, laboratories, and coordination bodies. It emphasizes standardized timelines, performance monitoring indicators, and decision-making protocols for outbreak management. The framework aims to improve system efficiency, reduce response delays, and strengthen integrated public health emergency management through clear operational guidance and accountability mechanisms.